Diablo III is top on my list. It will be great fun to play this one co-op with Christian, as soon as we put our second computer back into working order, that is. I still have fond memories of watching Christian play the Diablo II beta.
Next, I'm looking forward to Final Fantasy XIII. Hearing that this game will no longer be a PS3 exclusive is a big relief--I wasn't especially looking forward to purchasing that doomed ship just to play this game.
The last game I'm excited about is Starcraft II. But who isn't? That one speaks for itself.